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Hydroxyapatite BARONHAP® Type I&II Multimodal Chromatography Resins
Brief description Hydroxyapatite [Ca10(PO4)6(OH)2] is an inorganic pure-phase chromatography resin, which consists of spheres calcined at high temperatures. Its crystal structure is the same as that of hydroxyapatite in bone, with stable spherical structure and uniform particle sizes. Hydroxyapatite can interact with biomolecules in multiple modes to realize two separation mechanisms simultaneously: cation exchange and calcium metal affinity. The cation exchange mainly depends on the negatively charged phosphate groups on hydroxyapatite. Also, carboxyl clusters and phosphorus clusters on biomolecules can form stronger bonds with calcium on hydroxyapatite through metal affinity. Due to these unique separation mechanisms, hydroxyapatite has become an indispensable chromatography resin in today's extremely demanding downstream processes and plays an important role in the fields of biopharmaceuticals such as antibodies, vaccines (bacterial polysaccharides, pneumonia polysaccharides, and viruses), nucleic acids, enzymes, and recombinant proteins.
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Update time：2025-06-18
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Detailed Introduction

Features of Hydroxyapatite BARONHAP® Type I&II Multimodal Chromatography Resin


  • * Inorganic pure-phase multimodal chromatography resin with a stable structure.

  • * Supporting multiple separation modes, including cation exchange, calcium affinity, and separation by hydroxyl groups.


Specifications of Hydroxyapatite BARONHAP® Type I&II Multimodal Chromatography Resin


Hydroxyapatite prepacked column


Product Inner diameter × Column bed
(mm) 		Mean
particle size
(μm) 		Max. back
pressure
(MPa) 		Recommended
flow velocity
(mL/min) 		Quantity Product code
Chrom-Trap
BARONHAP® type I, 40 μm 1 mL 		7.7/25 40 3 1 1 × 1 mL 2010-1121
Chrom-Screen
BARONHAP® type I, 40 μm 4.7 mL 		7.7/100 40 3 1 – 4.7 1 × 4.7 mL 2010-1122
Chrom-Trap
BARONHAP® type I, 40 μm 5 mL 		16/25 40 3 1 – 5 1 × 5 mL 2010-1123
Chrom-Trap
BARONHAP® type II, 40 μm 1 mL 		7.7/25 40 4 1 1 × 1 mL 2011-1121
Chrom-Screen
BARONHAP® type II, 40 μm 4.7 mL 		7.7/100 40 4 1 – 4.7 1 × 4.7 mL 2011-1122
Chrom-Trap
BARONHAP® type II, 40 μm 5 mL 		16/25 40 4 1 – 5 1 × 5 mL 2011-1123

Hydroxyapatite chromatography resin


Product Max. back pressure
(MPa) 		Max. flow velocity
(cm/h) 		Mean particle size
(μm) 		Quantity Product code
BARONHAP® type I 3 400 20 μm 10 g 1110-1111
25 g 1110-1112
100 g 1110-1113
1 kg 1110-1114
5 kg 1110-1115
40 μm 10 g 1110-1121
25 g 1110-1122
100 g 1110-1123
1 kg 1110-1124
5 kg 1110-1125
60 μm 10 g 1110-1131
25 g 1110-1132
100 g 1110-1133
1 kg 1110-1134
5 kg 1110-1135
80 μm 10 g 1110-1141
25 g 1110-1142
100 g 1110-1143
1 kg 1110-1144
5 kg 1110-1145
BARONHAP® type II 4 400 20 μm 10 g 1111-1111
25 g 1111-1112
100 g 1111-1113
1 kg 1111-1114
5 kg 1111-1115
40 μm 10 g 1111-1121
25 g 1111-1122
100 g 1111-1123
1 kg 1111-1124
5 kg 1111-1125
60 μm 10 g 1111-1131
25 g 1111-1132
100 g 1111-1133
1 kg 1111-1134
5 kg 1111-1135
80 μm 10 g 1111-1141
25 g 1111-1142
100 g 1111-1143
1 kg 1111-1144
5 kg 1111-1145
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