Customer Hotline：+1 6193853151
Customer Hotline：+1 6193853151
Product Model：5L/10L/20L/50L Manufacturer nature：Manufacturer Update time：2025-06-15 Visits：209 product catalog
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Detailed Introduction
In response to the market demand, BioLink has developed BioHub®Fill Single-use Bulk Filling system. This automated solution enables accurate and efficient filling. While reducing overall production costs, it improves production efficiency and meets data recording compliance requirements.
Take the 500 L production line of an antibody customer with the bulk product of about 80 L as an example:
| Item | Automated Filling | Manual Filling |
| Personnel/Time | 2 operators/1 h | 3 operators/3 h |
| Labor Operating Cost (CNY/lot) | 600 | 2700 |
| Consumables Cost (CNY/lot) | A | A |
| Fixed Cost (W) | 80 (for reference only) | 10 (for reference only) |
| Filling Accuracy | ≤ ±0.6% | Uncontrollable |
| Contamination Risk | Very low | Moderate |
| Scalability | Support scaling | Additional staffing is required if production increases |
| Compliance |
Password complexity Three-level permissions Data recording Audit trail |
Complexity of manual recording Trivialness of SOP handwriting Mobility of personnel |
| Automated Manual Filling | Dual modes: |
| • Manual mode for determining key parameters by admin before filling | |
| • Automated mode for fully automated filling during user's production | |
| High Accuracy | PID adjustment enables precise linkage between the weighing signal and the peristaltic pump signal, achieving filling accuracy as low as ≤ ±0.6% |
| High Flexibility and Compatibility | Customizable dispensing brackets for freeze-thaw boxes & bottles of different brands and specifications |
| Bubble-free and Low Residual | Unique hardware structure with highly sensitive sensors for bubble-free filling and low residual recovery |
| Manifold Leak Test | Set process parameters based on tubing specifications for automated integrity testing |
| Real-Time Pressure Monitoring | Peristaltic pumps and pressure values are linked to greatly reduce the risk in filling |
| Data Traceability & Integrity | Real-time data recording, audit trails, data alarms, and electronic signatures meet the requirements of FDA 21 CFR Part 11; Interfaces available for interaction with other systems |
For high-precision sterile filling, matching consumables are essential. BioLink offers customizable filling consumables based on the bracket sizes, software logic design and usage requirements. For non-critical components, alternatives can be provided, such as pressure sensors for whole process monitoring rather than control. Other critical components such as manifold, sterile filters and connectors can be customized as required.
| Item | Automated Filling |
| Components | ① Control cabinet |
| ② Dispensing bracket | |
| ③ Pump | |
| Equipment Dimensions | Control cabinet (mm): 1052*689*1567 |
| Dispensing bracket: Customizable | |
| Equipment Weight | Control cabinet (kg): 110 |
| Dispensing bracket: Customizable | |
| Compatibility | Compitable with freeze-thaw boxes and bottles of different brands and specifications |
| Dispensing Bag/Bottle Limits | 18 |
| Supported Freeze-thaw Box/Bottle Sizes | 5L/10L/20L/50L (bags) |
| 5L/10L/20L (bottles) | |
| Filling Accuracy | ≤ ±0.6% (PID adjustment of pump) |
| Disconnection Method | Manual sealer/Electric cutter |
| Valve | Electric valve/Pinch valve |
| Pump | Diaphragm pump/Peristaltic pump |
| Weighing Mode | Overall 4-point weighing |
| Label Printer | Support freezing at -80°C, customizable printed information |
| Barcode Scanner | Standard configuration |
| Display | Advantech IPC/Siemens IPC |
| Slave Device | Siemens S7-1200 series |
| Power Supply/Power | 220V/2000W |
*For any other automated filling requirements, please contact BioLink technical team for customization.
