Antigen Name:

Pertuzumab specific antigen (His tag), a dedicated antigen for antibodies that specifically bind to the extracellular region II of ErbB2 (NP_004439.2).

background:

Human epidermal growth factor receptor 2 (Her-2) is a transmembrane glycoprotein with receptor tyrosine kinase (RTK) activity encoded by the proto-oncogene CerbB2 (Her2/neu) . It belongs to the epidermal growth factor receptor family, which includes HER1 (erbB1, EGFR), HER2 (erbB2, NEU), HER3 (erbB3) and HER4 (erbB4). Studies have shown that ErbB2/HER2 has gene amplification and protein overexpression in 20% to 30% of primary invasive ductal breast carcinoma. Trastuzumab and Pertuzumab are both monoclonal antibodies that bind to the extracellular domain of ErbB2/HER2, but the two have different binding sites. Pertuzumab binds to the extracellular domain II of the ErbB2/HER2 receptor, while trastuzumab binds to the extracellular domain IV of the HER2 receptor.

Sequence source:

The pertuzumab specific antigen (His tag) is the extracellular domain I-III region of human ErbB2 (NP_004439.2) expressed by Chinese hamster ovary (CHO) cells.

Molecular Weight:

The molecular weight of the protein in SDS-PAGE reduction electrophoresis was 75-85 kDa.

Reagent packaging:

Buffer: 10% glycerol, 100 mM Gly, 25 mM Tris, pH 7.3.

application:

Pertuzumab monoclonal antibody, in cell culture medium, animal and human serum, and dairy products .

purity:

Purity in SDS-PAGE reduction electrophoresis>95%;

concentration:

1mg/ml.

Storage conditions:

This product can be stored at -70℃ for 36 months; at -20℃ for 12 months; at 2~8℃ for 1 month.

Please avoid repeated freezing and thawing.