background:

ILDR2 belongs to the immunoglobulin superfamily. It may be involved in lipid homeostasis and endoplasmic reticulum stress pathways. ILDR2 is a novel B7-like protein with potent T-cell suppressive activity expressed on immune cells and in immune-privileged and inflamed tissues. A fusion protein consisting of the ILDR2 extracellular domain and the Fc fragment, bound to its putative counterpart on activated T cells, showed beneficial effects in a collagen-induced arthritis model and abolished the production of proinflammatory cytokines and chemokines in autologous synovial-like co-cultures of macrophages and cytokine-stimulated T cells. Collectively, these findings suggest that ILDR2 is a novel negative regulator of T cells with a potential role in the development of immune-related diseases, including autoimmunity and cancer.

Overview:

Antigen name: Human ILDR2 Protein, Fc Tag;

Other names: ILDR2, C1orf32;

Sequence source: Human ILDR2, Fc tag (IL2-H5259) expressed in human 293 cells (HEK293) with Fc tag;

Molecular Weight: The calculated molecular weight of this protein is 45.1 kDa . Due to glycosylation, the protein migrates at 45-50 kDa under reducing conditions (SDS-PAGE) .

Packing Specifications:

Rhinogen ^® recombinant human ILDR2 protein (Fc tag) packaging specifications are as follows:

characteristic:

Purity: Purity in SDS-PAGE reduction electrophoresis> 95%.

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.

Frequently asked questions