background:

B7-H7 (HHLA2) is a newly discovered B7 family member that regulates human T cell function. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associated 2 (HHLA2) with unknown function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. In the presence of TCR signaling, the B7-H7-CD28H pathway strongly promotes CD4+ T cell proliferation and cytokine production through an AKT-dependent signaling cascade, indicating that B7-H7 contains a novel co-stimulatory pathway. The first IgV domain of B7-H7 may bind to a putative receptor and shows the highest homology with other B7 family members.

Overview:

Antigen name: Human B7-H7 / HHLA2 Protein, Fc Tag;

Other names: B7-H7, HHLA2, B7 homolog 7;

Sequence source: Human B7-H7, Fc tag (B77-H5257) expressed in human 293 cells (HEK293) with Fc tag;

Molecular Weight: The calculated molecular weight of this protein is 63.4 kDa . Due to glycosylation, the protein migrates at 70-90 kDa under reducing conditions (SDS-PAGE) .

Packing Specifications:

Rhinogen® recombinant human B7-H7 / HHLA2 protein (Fc tag) packaging specifications are as follows ^:

characteristic:

Purity: Purity in SDS-PAGE reduction electrophoresis> 95%.

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.