background:

Cluster of differentiation 70 (CD70), also known as CD27 ligand (CD27L/CD27LG), TNFSF7 TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T and B lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces priming, effector function, differentiation, and memory formation of T cells and is therefore implicated in biological processes including T cell activation, proliferation of co-stimulated T cells, and generation of cytolytic T cells. CD70 on T cells provides the co-stimulatory signals required for T cell proliferation, clonal expansion, and promotion of effector T cell formation. CD70 on mouse B cells has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhance commitment to memory B cell responses. CD70 induces proliferation and IFNγ production on NK cells.

Overview:

Antigen name: Human CD27 Ligand / CD70 Protein, Fc Tag;

Other names: CD70, CD27LG, TNFSF7, TNFSF7G, CD27L;

Sequence source: Human CD27 ligand protein Fc tag (CDL-H5266) expressed by human 293 cells (HEK293) with Fc tag;

Molecular Weight: The calculated molecular weight of this protein is 74.1 kDa . Due to glycosylation, the protein migrates at 130-150 kDa under non-reducing conditions (SDS-PAGE) .

Packing Specifications:

Rhinogen ^® recombinant human CD27 Ligand / CD70 protein (Fc tag) packaging specifications are as follows:

characteristic:

Purity: Purity>95% in SDS-PAGE non-reducing electrophoresis.

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.