background:

Cluster of differentiation 70 (CD70), also known as CD27 ligand (CD27L/CD27LG), TNFSF7 TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T and B lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces priming, effector function, differentiation, and memory formation of T cells and is therefore implicated in biological processes including T cell activation, proliferation of co-stimulated T cells, and generation of cytolytic T cells. CD70 on T cells provides the co-stimulatory signals required for T cell proliferation, clonal expansion, and promotion of effector T cell formation. CD70 on mouse B cells has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhance commitment to memory B cell responses. CD70 induces proliferation and IFNγ production on NK cells.

Overview:

Antigen name: Human CD27 Ligand / CD70 Protein, His, Tag ;

Other names: CD70, CD27LG, TNFSF7, TNFSF7G, CD27L;

Sequence source: Human CD27 Ligand Protein, His, Flag Tag (CDL-H52Da) expressed by Human 293 cells (HEK293) with His tag;

Molecular weight: The calculated molecular weight of this protein is 49.3 kDa . Due to glycosylation, under non-reducing conditions (SDS-PAGE) When calibrated against the Star Ribbon prestained protein marker, the protein migrated at 50-60 kDa .

Packing Specifications:

Rhinogen ^® recombinant human CD27 Ligand / CD70 protein (His tag) packaging specifications are as follows:

characteristic:

Purity: Purity in SDS-PAGE reduction electrophoresis> 95%.

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.