background:

TIMP Metallopeptidase Inhibitor 1 also known as TIMP1, Tissue Inhibitor of Metalloproteinases, is a glycoprotein expressed from several tissues of an organism. This protein is a member of the TIMP family. This family has four members, TIMP1, TIMP2, TIMP3 and TIMP4. TIMP1 is a glycoprotein with a molecular weight of 28 kDa that is produced by a variety of cell types. The glycoprotein is a natural inhibitor of matrix metalloproteinases (MMPs), a group of peptidases involved in the degradation of the extracellular matrix. In addition to its inhibitory effects on most known MMPs, the encoded protein is able to promote cell proliferation in a variety of cell types and may also have anti-apoptotic functions. Transcription of this gene is highly inducible by many cytokines and hormones. In addition, expression from some but not all inactive X chromosomes suggests that inactivation of this gene is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Overview:

Antigen name : Human TIMP1 Protein, His Tag;

Other names : TIMP1, CLGI, TIMP;

Sequence source : human TIMP1, His tag (TI1-H5226) expressed from human 293 cells (HEK293) with a His tag;

Molecular Weight : The calculated molecular weight of this protein is 21.5 kDa . Due to glycosylation, the protein migrates at 30-34 kDa under reducing conditions (SDS-PAGE) .

Packing Specifications:

Rhinogen ^® recombinant human TIMP1 protein (His tag) packaging specifications are as follows:

characteristic:

Purity: Purity in SDS-PAGE reduction electrophoresis> 95%.

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.