background:

Siglecs (sialic acid-binding Ig-like lectins) are a unique subset of the Ig superfamily with an adhesion molecule-like structure. Here we describe a new member of the siglec protein family that has a similar structure, including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM signaling motifs. Siglec-10 was identified by database mining of an EST library of asthmatic eosinophils. The Siglec-10-VAP-1 interaction appears to mediate lymphocyte adhesion to endothelial cells and has the potential to alter the inflammatory microenvironment through enzymatic end products .

Overview:

Antigen name : Human Siglec-10 Protein, Fc Tag;

Other names : SIGLEC10, MGC126774, PRO940, Siglec10, SLG2;

Sequence source : Human Siglec-10, Fc tag (SI0-H5253) expressed by human 293 cells (HEK293) with Fc tag;

Molecular Weight : The calculated molecular weight of this protein is 84.6 kDa . Due to glycosylation, the protein migrates at 90-115 kDa under reducing conditions (SDS-PAGE) .

Packing Specifications:

Rhinogen ^® recombinant human Siglec-10 protein (Fc tag) packaging specifications are as follows:

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.

characteristic:

Purity: Purity in SDS-PAGE reduction electrophoresis> 95%.