background:

Tumor necrosis factor ligand superfamily member 14 (LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses through herpes virus entry mediator (HVEM) and lymphotoxin beta receptor ( LTbetaR ) signaling. LIGHT has emerged as a potent initiator of T cell co-stimulatory signals that influence CTL -mediated tumor rejection, allograft rejection, and graft-versus-host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune- like disease syndromes.

Overview:

Antigen name : Human LIGHT / TNFSF14 Protein, Fc Tag;

Other names : CD258 antigen, CD258, HVEM-L, LIGHT, LTg , TNFSF14, TR2, HVEML;

Sequence source : Human LIGHT protein, expressed by human 293 cells (HEK293), with Fc tag;

Molecular Weight : The calculated molecular weight of this protein is 58.3 kDa . Due to glycosylation, the protein migrates at 55-65 kDa under non-reducing conditions (SDS-PAGE) .

Packing Specifications:

Rhinogen® recombinant human LIGHT / TNFSF14 protein (Fc tag) packaging specifications are as follows ^:

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.

characteristic:

Purity: Purity>90% in SDS-PAGE non-reducing electrophoresis.