background:

Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in tissues. The main role of TNFα is to regulate immune cells. TNFα is able to induce apoptotic cell death, induce inflammation, inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been associated with a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under INN tasonermin . TNFα can be produced ectopically in the context of malignancy and, similar to parathyroid hormone, can cause secondary hypercalcemia and cancer associated with overproduction.

Overview:

Antigen name : Human TNF-alpha Protein, His Tag;

Other names : DIF, TNF-α, TNFA, TNFSF2, cachectin, cachectin, TNFα;

Sequence source : Human TNF-alpha protein, His Tag (TNA-H5228) expressed by 293 cells (HEK293), with His tag;

Molecular Weight : The calculated molecular weight of this protein is 18.3 kDa . Due to glycosylation, the protein migrates at 17-19 kDa when calibrated against the Star Ribbon prestained protein marker under reducing conditions (SDS-PAGE) .

Packing Specifications:

Rhinogen ^® recombinant human TNF-alpha protein (His tag) packaging specifications are as follows:

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.

characteristic:

Purity: Purity in SDS-PAGE reduction electrophoresis> 95%.