background:

B lymphocyte antigen CD20, also known as B lymphocyte surface antigen B1, leukocyte surface antigen Leu-16, transmembrane 4- domain subfamily A member 1, and MS4A1, is an activated glycosylated phosphoprotein expressed on the surface of all B cells, starting from the pre-B stage (CD45R+, CD117+), with increasing concentrations until maturity. CD20 is expressed at all stages of B cell development except the first and last stages; it is present on late pro-B cells to memory cells, but not on early pro-B cells or plasmablasts and plasma cells. It is present on B cell lymphomas, hairy cell leukemias, B cell chronic lymphocytic leukemias, and melanoma cancer stem cells. The protein has no known natural ligands and its function is to achieve optimal B cell immune responses, especially against T-independent antigens. It is suspected to act as a calcium channel in the cell membrane. CD20/MS4A1 is the target of the monoclonal antibodies ( mAbs ) rituximab , ibritumomab, tiuxetan , and tositumomab , all of which are active agents for the treatment of all B-cell lymphomas and leukemias. CD20/MS4A1 deficiency is the cause of common variant immunodeficiency 5 (CVID5); also known as antibody deficiency due to CD20 deficiency. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections, and an inability to mount an antibody response to antigens.

Overview:

Antigen name : Human CD20 / MS4A1 Full Length Protein, His Tag;

Other names : MS4A1, CD20, MS4A-1;

Sequence source : Human CD20 full-length protein (CD0-H52H3) expressed by Human 293 cells (HEK293) with His tag;

Molecular Weight : The calculated molecular weight of this protein is 35.2 kDa . Due to glycosylation, the protein migrates at 40 kDa under reducing conditions (SDS-PAGE) .

Packing Specifications:

Rhinogen ^® Recombinant Human CD20 / MS4A1 Full Length Protein (His Tag) packaging specifications are as follows:

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.

characteristic:

Purity: Purity in SDS-PAGE reduction electrophoresis> 85%.