background:

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on most human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immunoreceptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of LAIR-1 antigen on natural killer (NK) cells results in a strong inhibition of NK cell- mediated cytotoxicity.

As an inhibitory receptor, it constitutively negatively regulates the cytolytic function of natural killer (NK) cells, B cells, and T cells. Activation of Tyr phosphorylation leads to the recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase in intracellular calcium caused by B cell receptor ligation. Diseases associated with LAIR1 include chronic active Epstein-Barr virus infection and palindromic rheumatic disease.

Overview:

Antigen name : Human LAIR1 / CD305 Protein, Fc Tag;

Other names : Lyle 1, CD305;

Sequence source : human LAIR-1, Fc tag (LA1-H5252) expressed by human 293 cells (HEK293) with Fc tag;

Molecular Weight : The calculated molecular weight of this protein is 42.1 kDa . Due to glycosylation, the protein migrates at 55 kDa under reducing conditions (SDS-PAGE) .

Packing Specifications:

Rhinogen® recombinant human LAIR1 / CD305 protein (Fc tag) packaging specifications are as follows ^:

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.

characteristic:

Purity: Purity in SDS-PAGE reduction electrophoresis> 95%.