background:

Full-length tissue factor (TF) is a transmembrane receptor and cofactor for factor (F)VII/ FVIIa . In addition to full-length TF, an alternatively spliced (as) form of TF can be produced that lacks the transmembrane domain and is released from the cell. Compared to TF, asTF has low procoagulant activity because it lacks the transmembrane domain. Tissue factor is expressed by cells surrounding blood vessels, such as adventitial fibroblasts, and by body surface cells, such as epithelial cells, and plays a key role in hemostasis. TF also contributes to various forms of thrombosis. Many cancers, especially adenocarcinomas, express high levels of TF. High levels of tumor TF expression are associated with poor prognosis in many types of cancer, including breast, prostate, colorectal, and pancreatic cancers.

Overview:

Antigen name : Human Coagulation Factor III / Tissue Factor Protein, Fc Tag;

Other names : coagulation factor III, tissue factor, TF, F3, CD142;

Sequence source : Human tissue factor Fc tag (TF3-H5253) expressed by human 293 cells (HEK293) with His tag;

Molecular Weight : The calculated molecular weight of this protein is 51.2 kDa . Due to glycosylation, the protein migrates at 60-66 kDa under reducing conditions (SDS-PAGE) .

Packing Specifications:

Rhinogen ^® recombinant human Coagulation Factor III / Tissue Factor protein (Fc tag) packaging specifications are as follows:

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.

characteristic:

Purity: Purity in SDS-PAGE reduction electrophoresis> 95%.