background:

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is located in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors, which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). This receptor is expressed on immune cells, where it binds to MHC class I molecules on antigen-presenting cells and transduces negative signals that inhibit the stimulation of immune responses. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Overview:

Antigen name : Human LILRB1 / CD85j / ILT2 Protein, Fc Tag;

Other names : CD85J, LILRB1, CD85, ILT2, LIR1, MIR7;

Sequence source : Human LILRB1, Fc tag (CDJ-H5252) expressed in human 293 cells (HEK293) with Fc tag;

Molecular Weight : The calculated molecular weight of this protein is 73.8 kDa . Due to glycosylation, the protein migrates at 90-105 kDa under reducing conditions (SDS-PAGE) .

Packaging specifications:
Rhinogen® recombinant human LILRB1/CD85j/ILT2 protein (Fc tag) packaging specifications are as follows ^:

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.

Characteristics:
Purity: Purity in SDS-PAGE reduction electrophoresis>92%.