background:

ICOS ligand (ICOSLG), also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1), and CD antigen CD275, belongs to the immunoglobulin superfamily and the BTN/MOG family. ICOSLG contains an Ig-like C2-type (immunoglobulin-like) domain and an Ig-like V-type (immunoglobulin-like) domain. Subtype 1 is widely expressed, while subtype 2 is only detected in lymph nodes, leukocytes, and spleen. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a co-stimulatory signal for T-cell proliferation and cytokine secretion, and also induces B-cell proliferation and differentiation into plasma cells. B7-H2 may play an important role in mediating the response of local tissues to inflammation and regulating secondary immune responses by co-stimulating memory T-cell function.

Overview:

Antigen name : Human B7-H2 / ICOSLG Protein, Fc Tag;

Other names : ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, ICOS ligand;

Sequence source : Human B7-H2, Fc tag (B72-H5254) expressed by human 293 cells (HEK293) with Fc tag;

Molecular Weight : The calculated molecular weight of this protein is 53.1 kDa . Due to glycosylation, the protein migrates at 66-90 kDa under reducing conditions (SDS-PAGE) .

Packaging specifications:
Rhinogen ^® recombinant human B7-H2 / ICOSLG protein (Fc tag) packaging specifications are as follows:

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.

Characteristics:
Purity: Purity in SDS-PAGE reduction electrophoresis>95%.