Background:
Tumor necrosis factor ligand superfamily member 4 (TNFSF4), also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptional activator glycoprotein 1, and CD252, belongs to the tumor necrosis factor family. TNFSF4 is a ligand for CD134 and is expressed on cells such as DC2s (a subtype of dendritic cells) to amplify Th2 cell differentiation. TNFSF4-TNFSF4 interactions are involved in the pathogenesis of a variety of autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease, and cancer. In addition, similar to other TNF superfamily members, membrane-bound OX40 ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.

Overview:
Antigen name: Human OX40 Ligand / TNFSF4 Protein, Fc Tag; Other names: OX40L, TNFSF4, CD252, Glycoprotein Gp34, TXGP1, CD134 Ligand, CD134L; Sequence source: Human OX40 Ligand, Fc Tag, High Quality (OXL-H5266) expressed by human 293 cells (HEK293) with Fc tag;
Molecular weight: The calculated molecular weight of this protein is 74.0 kDa . Due to glycosylation, the protein migrates at 140-200 kDa under non-reducing conditions (SDS-PAGE) .

Packing Specifications:

Rhinogen® recombinant human OX40 Ligand / TNFSF4 protein (Fc tag) packaging specifications are as follows ^:

Characteristics:
Purity: Purity in SDS-PAGE non-reducing electrophoresis>90%.

Storage temperature:
This product can be stored for 12 months in a freeze-dried state at -20°C to -70°C; after reconstitution, it can be stored for 3 months at -70°C under sterile conditions. Please avoid repeated freezing and thawing.