Background:
B7-1 and B7-2 and their receptors CD28 and CTLA4 constitute one of the major co-stimulatory pathways regulating T-cell and B-cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with 20-100 times higher affinity than CD28 and is involved in the downregulation of immune responses. B lymphocyte activation antigen B7-1 (B7 for short), also known as cluster of differentiation 80 (CD80), is a member of the cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages, and dendritic cells. It is a ligand for two different proteins on the surface of T cells: CD28 (for autoregulation and cell-to-cell binding) and CTLA-4 (for downregulation and cell dissociation). CD80 works in conjunction with CD86 to prime T cells. CD80 plays a role in the induction of innate immune responses by activating the NF-κB signaling pathway in macrophages. Therefore, CD80 is considered a promising therapeutic target for autoimmune diseases and various cancers.
Overview:
Antigen name: Human B7-1 / CD80 Protein, Fc Tag; Other names: CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7; Sequence source: Human B7-1, Fc tag (B71-H5259) is expressed by human 293 cells (HEK293) with Fc tag; Molecular weight: The calculated molecular weight of this protein is 50.0 kDa . Due to glycosylation, the protein migrates at 65-90 kDa under reducing (R) conditions (SDS-PAGE) .
Packaging specifications:
Rhinogen ^® recombinant human B7-1 / CD80 protein (Fc tag) packaging specifications are as follows:

Characteristics:
Purity: Purity in SDS-PAGE reduction electrophoresis>95%.
Storage temperature:
This product can be stored for 12 months in a freeze-dried state at -20°C to -70°C; after reconstitution, it can be stored for 3 months at -70°C under sterile conditions. Please avoid repeated freezing and thawing.