background:

Tyrosine protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1), belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig -like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression level drops sharply around day 16 and is only at very low levels in adult tissues. The Short isoform is strongly expressed in the fetal and adult central nervous system and in a variety of human cancers, including those arising from the neuroectoderm of the CNS or PNS. ROR1 can interact with casein kinase 1 ε (CK1ε) to activate phosphoinositide 3-kinase- mediated phosphorylation of AKT and cAMP response element binding protein (CREB), which is associated with enhanced tumor cell growth.

Overview:

Antigen name : Human / Cynomolgus / Rhesus macaque ROR1 Protein, Fc Tag;

Other names : ROR1, NTRKR1;

Sequence source : Human/Cynomolgus/Rhesus ROR1, Fc tag (RO1-H5250) expressed in human 293 cells (HEK293) with Fc tag;

Molecular Weight : The calculated molecular weight of this protein is 68.6 kDa . Due to glycosylation, the protein migrates at 79-95 kDa under reducing (R) conditions (SDS-PAGE) .

characteristic:

Purity : Purity in SDS-PAGE reduction electrophoresis> 90%.

Packing Specifications:

Rhinogen ^® recombinant human/monkey/cynomolgus ROR1 protein (Fc tag) packaging specifications are as follows:

Storage temperature:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.