background:

Nectin-4 ( Nectin cell adhesion molecule 4) is a family of nectin and nectin -like cell adhesion molecules. It is present in high levels in normal embryonic and fetal tissues, but decreases in adulthood and has limited distribution in healthy tissues. Nectin-4 is overexpressed in a variety of tumor cells, promoting tumor cell growth and proliferation. Solid tumors with high expression of nectin-4 include bladder cancer, pancreatic cancer, triple-negative breast cancer, non-small cell lung cancer, gastric cancer, esophageal cancer, ovarian cancer and many other cancers. Studies have found that nectin-4 promotes tumor cell proliferation, differentiation, migration and invasion by activating the PI3K/Akt pathway, and is believed to play an important role in the occurrence and metastasis of cancer. It is based on these research backgrounds that drug research targeting this target has emerged.

Overview:

Antigen name : HumanNectin-4 Protein, Fc Tag;

Other names : NECTIN4, LNIR, PRR4, PVRL4;

Sequence source : Human Nectin-4, Fc tag (NE4-H5255) expressed in human 293 cells (HEK293). With Fc tag;

Molecular Weight : The calculated molecular weight of this protein is 60.5 kDa . Due to glycosylation, the protein migrates at 65-70 kDa under reducing (R) conditions (SDS-PAGE) .

Reagent packaging:

Rhinogen ^® HumanNectin-4 Protein, Fc Tag packaging specifications are as follows:

Product Features:

Purity: Purity in SDS-PAGE reduction electrophoresis> 95%.

Storage conditions:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months. Please avoid repeated freezing and thawing.