background:

ErbB3, also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin-binding domain but no active kinase domain. Therefore, it can bind ligands but cannot mediate intracellular signal transduction through protein phosphorylation . However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to generate receptor complexes and initiate relevant pathways, leading to cell proliferation or differentiation. This protein has been reported to be overexpressed in many cancers, including prostate, bladder, and breast tumors. The protein has different isoforms derived from alternative splicing variants, among which the secreted isoform lacking the intermembrane region regulates the activity of the membrane-bound form.

Overview:

Antigen name : Human ErbB3 / Her3 Protein, Mouse IgG2a Fc Tag;

Other names : ERBB3, HER3, LCCS2, MDA-BF-1, MGC88033, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3;

Sequence source : Human ErbB3, Mouse IgG2a Fc Tag (ER3-H5257) expressed by human 293 cells (HEK293) with His tag;

Molecular Weight : The calculated molecular weight of this protein is 95.5 kDa . Due to glycosylation, the protein migrates at 115 kDa under reducing (R) conditions (SDS-PAGE) .

Reagent packaging:

Rhinogen ^® Human ErbB3 / Her3 Protein, Mouse IgG2a Fc Tag packaging specifications are as follows:

Product Features:

Purity: Purity in SDS-PAGE reduction electrophoresis> 90%.

Storage conditions:

This product can be stored in a freeze-dried state at -20°C to -70°C for 12 months; after reconstitution, it can be stored at -70°C under sterile conditions for 3 months.

Please avoid repeated freezing and thawing.