Antigen Name:

 Recombinant human B7-H2 / ICOSLG protein (His Tag)/Human B7-H2 / ICOSLGProtein , His Tag;

Other Names:

ICOSLG, B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS, ICOS ligand;

background:

ICOS ligand (ICOSLG), also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1), and CD antigen CD275, belongs to the immunoglobulin superfamily and the BTN/MOG family. ICOSLG contains an Ig-like C2-type (immunoglobulin-like) domain and an Ig-like V-type (immunoglobulin-like) domain. Isozyme 1 is widely expressed, while isozyme 2 is only detected in lymph nodes, leukocytes, and spleen. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 is an agonist signal for T-cell proliferation and cytokine secretion, and can also induce B-cell proliferation and differentiation into plasma cells. B7-H2 can play an important role in mediating the response of local tissues to inflammatory conditions and regulating secondary immune responses by co-stimulating memory T-cell function.

Sequence source:

Human B7-H2 / ICOSLGProtein , His Tag, expressed by Chinese hamster ovary (CHO) cells; protein number NP_056074 (Asp19 - Ser258), with His tag;

Molecular Weight:

The theoretical molecular weight is 28.58 kDa. Due to glycosylation, the molecular weight of SDS-PAGE reduction electrophoresis is 45-67 kDa.

Specifications:

purity:

SDS-PAGE electrophoresis purity> 99%;

application:

Monoclonal antibody for quantitative detection of HumanB7-H2 / ICOSLG Protein in cell culture medium, serum and milk.

Buffer:

20mM PB, 150mM NaCl, pH7.4;

Storage conditions:

This product can be stored at -20℃~-70℃ for 12 months; after reconstitution, it can be stored at -70℃ under sterile conditions for 3 months. Please avoid repeated freezing and thawing.