Antigen Name:

Recombinant human Nectin-4 protein (His tag)/Human Nectin-4Protein, HisTag;

Other Names:

NECTIN4, LNIR, PRR4, PVRL4;

background:

Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein that belongs to the Ig superfamily protein Nectin family. Nectin is a cell adhesion molecule that plays a key role in various biological processes such as polarity, proliferation, differentiation and migration during the development and adulthood of epithelial cells, endothelial cells, immune cells and neural cells. In breast cancer, ovarian cancer and lung cancer, 50%, 49% and 86% of tumor-associated antigens are Nectin-4, respectively, and most of them are tumors with poor prognosis. Its expression is not detected in the corresponding normal tissues.

Sequence source:

Human Nectin-4 Protein, HisTag is expressed by Chinese hamster ovary (CHO) cells; the protein number is Q96NY8-1 (Gly32 - Ser349), with His tag;

Molecular Weight:

The theoretical molecular weight is 36 kDa. Due to glycosylation, the molecular weight of SDS-PAGE reduction electrophoresis is 40 kDa.

Specifications:

purity:

SDS-PAGE electrophoresis purity> 99%;

application:

Monoclonal antibody used for quantitative detection of Human Nectin-4 Protein in cell culture medium, serum and milk.

Buffer:

20mM PB, 150mM NaCl, pH7.4;

Storage conditions:

This product can be stored at -20℃~-70℃ for 12 months; after reconstitution, it can be stored at -70℃ under sterile conditions for 3 months. Please avoid repeated freezing and thawing.