Antigen Name:

Recombinant human ErbB3 / Her3 protein (Fc tag)/Human ErbB3 / Her3 Protein, Fc Tag;

Other Names:

ERBB3, HER3, LCCS2, MDA-BF-1, MGC88033, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3;

background:

ErbB3, also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuroligin binding domain but no active kinase domain. Therefore, it can bind to ligands but cannot mediate intracellular signal transduction through protein phosphorylation . However, it can form heterodimers with ErbB2 or other epidermal growth factor receptor members, responsible for tyrosine phosphorylation, thereby forming a receptor complex and initiating related pathways, leading to cell proliferation or differentiation. This protein has been reported to be overexpressed in a variety of cancers, including prostate cancer, bladder cancer, and breast cancer. This protein has different isoforms, which come from different splicing variants, among which the secreted isoform lacking the intermembrane region can regulate the activity of the membrane-bound type.

Sequence source:

Human ErbB3 / Her3 Protein, Fc Tag is expressed by Chinese Hamster Ovary (CHO) cells; the protein number is NP_001973.2 (Ser20 - Thr643), with Fc tag;

Molecular Weight:

The theoretical molecular weight is 95.4 kDa. Due to glycosylation, the molecular weight of SDS-PAGE reduction electrophoresis is 116-130 kDa .

Specifications:

If you need large packages, please contact customer service at 0512-87663137, or send an email to sales@rhinobio.com.

purity:

SDS-PAGE electrophoresis purity> 85%;

application:

Monoclonal antibody for quantitative detection of HumanErbB3 / Her3 Protein in cell culture medium, serum and milk.

Buffer:

20mM PB, 150mM NaCl, pH7.4;

Storage conditions:

This product can be stored at -20℃~-70℃ for 12 months; after reconstitution, it can be stored at -70℃ under sterile conditions for 3 months. Please avoid repeated freezing and thawing.