Antigen Name:

Human PCSK9 Protein, His Tag

Other Names:

PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9;

background:

Proprotein convertase tilisin /kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis-regulating convertase), is a newly discovered subclass of peptidase that belongs to the S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in cleavage of its front peptide, which remains associated with the secretory active enzyme with a broad alkaline pH range. The protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR) and induces LDLR degradation. PCSK9 may also play a role in the differentiation of cerebral cortical neurons. Mutations in this gene are associated with a rare autosomal dominant familial hypercholesterolemia (HCHOLA3).

Sequence source:

Human PCSK9 Protein, His Tag is expressed by Chinese hamster ovary (CHO) cells; the protein number is Q8NBP7-1 (Gln31-Gln692), with a His tag.

Molecular Weight:

The theoretical molecular weight is 13.8 kDa and 59.2 kDa. Due to glycosylation, the molecular weight of SDS-PAGE reduction electrophoresis is 17 kDa and 65-70 kDa.

Specifications:

If you need large packages, please contact customer service at 0512-87663137, or send an email to sales@rhinobio.com.

purity:

SDS-PAGE electrophoresis purity>95%;

application:

Monoclonal antibody used for quantitative detection of Human PCSK9 Protein in cell culture medium, serum and milk.

concentration:

1mg/ml;

Buffer:

20 mM PB, 0.15 M NaCl, pH 7.4, usually trehalose is added as a protective agent before lyophilization.

Storage conditions:

This product can be stored at -70℃ for 36 months; at -20℃ for 12 months; at 2-8℃ for 1 month. Please avoid repeated freezing and thawing.