Antigen Name:

Human Her2 / ErbB2 Protein,6×His Tag

Other Names:

ERBB2, CD340, HER-2, neu, HER2, MLN19, NEU, NGL, TKR1;

background:

Human epidermal growth factor receptor 2 (HER2), also known as ERBB2, HER-2, HER-2/neu, NEU, NGL, TKR1, and c- erb B2, is a protein that makes breast cancer more aggressive. It is a member of the ErbB family of proteins, commonly referred to as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase that is normally involved in signal transduction pathways that lead to cell growth and differentiation. HER2 is considered an orphan receptor and cannot be activated by ligands from the EGF family. Approximately 30% of breast cancers have amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play a role in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation.

Sequence source:

Human Her2 / ErbB2 Protein, 6×His Tag is expressed by Chinese hamster ovary (CHO) cells; the protein number is P04626-1 (Thr23-Thr652), with His tag;

Molecular Weight:

The theoretical molecular weight is 70.2 kDa. Due to glycosylation, the molecular weight of SDS-PAGE reduction electrophoresis is 110 kDa and 115 kDa.

Specifications:

If you need large packages, please contact customer service at 0512-87663137, or send an email to sales@rhinobio.com.

purity:

SDS-PAGE electrophoresis purity>95%;

application:

Monoclonal antibody for quantitative detection of HumanHer2 / ErbB2 Protein in cell culture medium, serum and milk.

concentration:

1mg/ml;

Buffer:

20mM PB, 0.15M NaCl, pH7.4;

Storage conditions:

This product can be stored at -70℃ for 36 months; at -20℃ for 12 months; at 2-8℃ for 1 month. Please avoid repeated freezing and thawing.