Antigen Name:

Recombinant human B7H4 ECD protein ( hFc tag).

background:

Recombinant human B7H4 ECD protein ( hFc tag) is a fusion protein of recombinant human B7H4 ECD (V-set domain containing T cell activation inhibitor 1) and human IgG1 Fc. V-set domain containing T cell activation inhibitor 1, also known as B7X, B7H4, B7S1 and VTCN1, belongs to the B7 family of co-stimulatory proteins. These proteins are expressed on the surface of antigen presenting cells and interact with ligands on T lymphocytes. They provide co-stimulatory signals that regulate T cell responses. Soluble forms of B7H4 have also been detected. B7X/VTCN1/B7H4 negatively regulate T cell- mediated immune responses by inhibiting T cell activation, proliferation, cytokine production and cytotoxic development. When expressed on the cell surface of tumor macrophages, B7X/VTCN1/B7H4, together with regulatory T cells (Treg), play an important role in suppressing tumor-associated antigen-specific T cell immunity. B7X/VTCN1/B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be upregulated by IL6/interleukin-6 and IL1/interleukin-1 and inhibited by CSF2/GM-CSF and IL4/interleukin-4.

Sequence source:

B7H4 is NM_024626.2, and hFc is the human IgG1 Fc region.

Specifications:

purity:

The purity in SDS-PAGE reduction electrophoresis was >95%.

concentration:

1mg/ml.

Buffer:

PBS, PH7.0.

Storage conditions:

This product can be stored at -20℃ for 12 months; at -70℃ for 36 months; at 2-8℃ for 1 month. Please avoid repeated freezing and thawing.