Antigen Name:

Recombinant human Siglec-15 protein (Mouse Fc tag).

background:

Recombinant human Siglec-15 protein (Human Fc tag) is a fusion protein of the extracellular end (20-263) of recombinant human Siglec-15 (Sialic acid-binding Ig-like lectin 15) and mouse IgG2a Fc. Human Siglec-15 was initially found to play a role in osteoclastogenesis. Recently, it was found to be a tumor immune checkpoint expressed in tumors similar to PDL1. Siglec-15 can also be expressed in human macrophages. Siglec-15 can act on an unknown inhibitory receptor on T cells to inhibit the activation/proliferation of T cells.

Sequence source:

Siglec-15 is NCBI GenBank: AAY40743.1, mouse FC is mouse IgG2a Fc.

Biological activity:

Siglec-15 can act on an unknown inhibitory receptor on T cells to inhibit the activation/proliferation of T cells.

application:

1. As an antigen, immunize animals to obtain antibodies;

2. ELISA;

3. Inhibition of T cell proliferation.

purity:

The purity in SDS-PAGE reduction electrophoresis was >90%.

concentration:

1mg/ml.

Buffer:

PBS, pH 7.4.

Storage conditions:

This product can be stored at -20℃ for 12 months and at 2-8℃ for 1 month. Please avoid repeated freezing and thawing.