background:

PD-1 (Programmed cell death protein 1) is an immunosuppressive molecule expressed in activated T cells and B cells. The tumor microenvironment induces infiltrating T cells to highly express PD-1 molecules. PD-L1 on tumor cells binds to PD-1 on T cells, inhibiting T cell proliferation and activation, rendering T cells inactive and ultimately inducing immune escape. Anti-PD-1 or anti-PD-L1 biological agents can block the binding of PD-1 to PD-L1.

Figure 1. Schematic diagram of Rhinogen ^® PD-1/PD-L1 Blockade Bioassay

Specifications:

Features:

The Rhinogen ^® PD-1/PD-L1 Blockade Bioassay test is characterized by its easy operation (Figure 2), high accuracy, and high sensitivity, making it suitable as an indicator for production batch release.

1. Clear principle: Based on the mechanism of action (MOA) of biologics that block the PD-1/PD-L1 interaction;

2. Simple operation: The detection process is simple, time-saving, and the detection reagents are easy to use;

3. High specificity: only responds to anti-PD-1 or anti-PD-L1 biological blockers;

4. Stable method: sensitive, accurate and precise, suitable as a production batch release indicator.

Figure 2. Rhinogen ^® PD-1/PD-L1 Blockade Bioassay Flowchart

Transportation and storage:

Transportation method: dry ice transportation

Storage: Upon receipt of cells, please immediately transfer the cryovials to a temperature below -140°C for long-term storage.